Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance mechanisms. GBM cells with stem-like properties (CS...

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Detalhes bibliográficos
Main Authors: Clark, Paul A, Iida, Mari, Treisman, Daniel M, Kalluri, Haviryaji, Ezhilan, Sathyapriya, Zorniak, Michael, Wheeler, Deric L, Kuo, John S
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384429/
https://ncbi.nlm.nih.gov/pubmed/22745588
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