Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance mechanisms. GBM cells with stem-like properties (CS...

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Bibliographische Detailangaben
Hauptverfasser: Clark, Paul A, Iida, Mari, Treisman, Daniel M, Kalluri, Haviryaji, Ezhilan, Sathyapriya, Zorniak, Michael, Wheeler, Deric L, Kuo, John S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384429/
https://ncbi.nlm.nih.gov/pubmed/22745588
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