Reduced Efficacy of the Plk1 Inhibitor BI 2536 on the Progression of Hepatocellular Carcinoma due to Low Intratumoral Drug Levels

Highly promising preclinical data obtained in cultured cells and in nude mice bearing xenografts contrast with the rather modest clinical efficacy of Polo-like kinase 1 (Plk1) inhibitors. In the present study, we investigated if Plk1 might be a suitable target in hepatocellular carcinoma (HCC) and i...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Haupenthal, Jörg, Bihrer, Verena, Korkusuz, Huedayi, Kollmar, Otto, Schmithals, Christian, Kriener, Susanne, Engels, Knut, Pleli, Thomas, Benz, Alexander, Canamero, Marta, Longerich, Thomas, Kronenberger, Bernd, Richter, Swantje, Waidmann, Oliver, Vogl, Thomas J, Zeuzem, Stefan, Piiper, Albrecht
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384428/
https://ncbi.nlm.nih.gov/pubmed/22745587
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items