Reduced Efficacy of the Plk1 Inhibitor BI 2536 on the Progression of Hepatocellular Carcinoma due to Low Intratumoral Drug Levels

Highly promising preclinical data obtained in cultured cells and in nude mice bearing xenografts contrast with the rather modest clinical efficacy of Polo-like kinase 1 (Plk1) inhibitors. In the present study, we investigated if Plk1 might be a suitable target in hepatocellular carcinoma (HCC) and i...

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Detalhes bibliográficos
Main Authors: Haupenthal, Jörg, Bihrer, Verena, Korkusuz, Huedayi, Kollmar, Otto, Schmithals, Christian, Kriener, Susanne, Engels, Knut, Pleli, Thomas, Benz, Alexander, Canamero, Marta, Longerich, Thomas, Kronenberger, Bernd, Richter, Swantje, Waidmann, Oliver, Vogl, Thomas J, Zeuzem, Stefan, Piiper, Albrecht
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384428/
https://ncbi.nlm.nih.gov/pubmed/22745587
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