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Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice
Fertilization requires taxon-specific gamete recognition, and human sperm do not bind to zonae pellucidae (ZP1–3) surrounding mouse eggs. Using transgenesis to replace endogenous mouse proteins with human homologues, gain-of-function sperm-binding assays were established to evaluate human gamete rec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384420/ https://ncbi.nlm.nih.gov/pubmed/22734000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201203062 |
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