Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice

Fertilization requires taxon-specific gamete recognition, and human sperm do not bind to zonae pellucidae (ZP1–3) surrounding mouse eggs. Using transgenesis to replace endogenous mouse proteins with human homologues, gain-of-function sperm-binding assays were established to evaluate human gamete rec...

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Sonraí Bibleagrafaíochta
Main Authors: Baibakov, Boris, Boggs, Nathan A., Yauger, Belinda, Baibakov, Galina, Dean, Jurrien
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2012
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384420/
https://ncbi.nlm.nih.gov/pubmed/22734000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201203062
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