Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

Epidermal growth factor receptor (EGFR) signaling is one of the crucial factors in breast cancer malignancy. Breast cancer cells often overexpress Arf6 and its effector, AMAP1/ASAP1/DDEF1; in these cells, EGFR signaling may activate the Arf6 pathway to induce invasion and metastasis. Active recyclin...

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Hlavní autoři: Onodera, Yasuhito, Nam, Jin-Min, Hashimoto, Ari, Norman, Jim C., Shirato, Hiroki, Hashimoto, Shigeru, Sabe, Hisataka
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384417/
https://ncbi.nlm.nih.gov/pubmed/22734003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201065
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