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The impact of the unfolded protein response on human disease

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis cause accumulation of misfolded/unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded protein r...

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Hlavní autoři: Wang, Shiyu, Kaufman, Randal J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384412/
https://ncbi.nlm.nih.gov/pubmed/22733998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110131
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