The involvement of Galectins in the modulation of the JAK/STAT pathway in myeloproliferative neoplasia

BACKGROUND: In patients with myeloproliferative neoplasia (MPN) the development of fibrosis and increased vessel density correlate with poor prognosis. The JAK2(V617F) mutation constitutively activates JAK2, which phosphorylates signal transducer activator of transcription (STAT), up-regulating vasc...

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Autores principales: Koopmans, Suzanne M, Bot, Freek J, Schouten, Harry C, Janssen, Jannie, van Marion, Arienne MW
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384397/
https://ncbi.nlm.nih.gov/pubmed/22762031
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