Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT signaling pathway related genes in circulating CD34(+) cells of MPNs. Regarding l...

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發表在:Mediators Inflamm
Main Authors: Čokić, Vladan P., Mitrović-Ajtić, Olivera, Beleslin-Čokić, Bojana B., Marković, Dragana, Buač, Marijana, Diklić, Miloš, Kraguljac-Kurtović, Nada, Damjanović, Svetozar, Milenković, Pavle, Gotić, Mirjana, Raj, Puri K.
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602333/
https://ncbi.nlm.nih.gov/pubmed/26491227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/453020
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