IL-6 stimulation of DNA replication is JAK1/2 mediated in cross-talk with hyperactivated ERK1/2 signaling

Myeloproliferative neoplasms (MPNs) are developing resistance to therapy by JAK1/2 inhibitor ruxolitinib. To explore the mechanism of ruxolitinib’s limited effect, we examined the JAK1/2 mediated induction of proliferation related ERK1/2 and AKT signaling by proinflammatory interleukin-6 (IL-6) in M...

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Detalles Bibliográficos
Publicado en:Cell Biol Int
Main Authors: Subotički, Tijana, Ajtić, Olivera Mitrović, Beleslin-Čokić, Bojana B., Bjelica, Sunčica, Djikić, Dragoslava, Diklić, Miloš, Leković, Danijela, Gotić, Mirjana, Santibanez, Juan F., Noguchi, Constance T., Čokić, Vladan P.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347554/
https://ncbi.nlm.nih.gov/pubmed/30571852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbin.11084
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