The involvement of Galectins in the modulation of the JAK/STAT pathway in myeloproliferative neoplasia

BACKGROUND: In patients with myeloproliferative neoplasia (MPN) the development of fibrosis and increased vessel density correlate with poor prognosis. The JAK2(V617F) mutation constitutively activates JAK2, which phosphorylates signal transducer activator of transcription (STAT), up-regulating vasc...

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Bibliografiske detaljer
Main Authors: Koopmans, Suzanne M, Bot, Freek J, Schouten, Harry C, Janssen, Jannie, van Marion, Arienne MW
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384397/
https://ncbi.nlm.nih.gov/pubmed/22762031
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