Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

Chemically modified siRNAs are expected to have resistance toward nuclease degradation and good thermal stability in duplex formation for in vivo applications. We have recently found that 2′-OMe-4′-thioRNA, a hybrid chemical modification based on 2′-OMeRNA and 4′-thioRNA, has high hybridization affi...

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Bibliografske podrobnosti
Main Authors: Takahashi, Mayumi, Nagai, Chisato, Hatakeyama, Hiroto, Minakawa, Noriaki, Harashima, Hideyoshi, Matsuda, Akira
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Synthetic Biology and Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384325/
https://ncbi.nlm.nih.gov/pubmed/22411910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks204
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