In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibi...

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Autors principals: Takahashi, Mayumi, Yamada, Naoki, Hatakeyama, Hiroto, Murata, Manami, Sato, Yusuke, Minakawa, Noriaki, Harashima, Hideyoshi, Matsuda, Akira
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Synthetic Biology and Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905841/
https://ncbi.nlm.nih.gov/pubmed/24030710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt823
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