Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, w...

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Main Authors: Jayathilaka, Nimanthi, Han, Aidong, Gaffney, Kevin J., Dey, Raja, Jarusiewicz, Jamie A., Noridomi, Kaori, Philips, Michael A., Lei, Xiao, He, Ju, Ye, Jun, Gao, Tao, Petasis, Nicos A., Chen, Lin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384312/
https://ncbi.nlm.nih.gov/pubmed/22396528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks189
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