Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, w...

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Detalhes bibliográficos
Main Authors: Jayathilaka, Nimanthi, Han, Aidong, Gaffney, Kevin J., Dey, Raja, Jarusiewicz, Jamie A., Noridomi, Kaori, Philips, Michael A., Lei, Xiao, He, Ju, Ye, Jun, Gao, Tao, Petasis, Nicos A., Chen, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384312/
https://ncbi.nlm.nih.gov/pubmed/22396528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks189
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