Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, w...

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Bibliografiset tiedot
Päätekijät: Jayathilaka, Nimanthi, Han, Aidong, Gaffney, Kevin J., Dey, Raja, Jarusiewicz, Jamie A., Noridomi, Kaori, Philips, Michael A., Lei, Xiao, He, Ju, Ye, Jun, Gao, Tao, Petasis, Nicos A., Chen, Lin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2012
Aiheet:
Gene Regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384312/
https://ncbi.nlm.nih.gov/pubmed/22396528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks189
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