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Synthesis of nucleic acid methylphosphonothioates.

The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral p...

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Autores principales: Roelen, H C, de Vroom, E, van der Marel, G A, van Boom, J H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1988
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC338431/
https://ncbi.nlm.nih.gov/pubmed/3412896
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