Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression

Extraordinary single-cell diversity is generated in the vertebrate nervous system by the combinatorial expression of the clustered protocadherin genes (Pcdhα, -β, and -γ). This diversity is generated by a combination of stochastic promoter choice and alternative pre-mRNA splicing. Here we show that...

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Detalles Bibliográficos
Main Authors: Monahan, Kevin, Rudnick, Noam D., Kehayova, Polina D., Pauli, Florencia, Newberry, Kimberly M., Myers, Richard M., Maniatis, Tom
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384188/
https://ncbi.nlm.nih.gov/pubmed/22550178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205074109
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