CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF)...

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Autori principali: Degner, Stephanie C., Verma-Gaur, Jiyoti, Wong, Timothy P., Bossen, Claudia, Iverson, G. Michael, Torkamani, Ali, Vettermann, Christian, Lin, Yin C., Ju, Zhongliang, Schulz, Danae, Murre, Caroline S., Birshtein, Barbara K., Schork, Nicholas J., Schlissel, Mark S., Riblet, Roy, Murre, Cornelis, Feeney, Ann J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111298/
https://ncbi.nlm.nih.gov/pubmed/21606361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019391108
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