CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF)...

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Bibliographische Detailangaben
Hauptverfasser: Degner, Stephanie C., Verma-Gaur, Jiyoti, Wong, Timothy P., Bossen, Claudia, Iverson, G. Michael, Torkamani, Ali, Vettermann, Christian, Lin, Yin C., Ju, Zhongliang, Schulz, Danae, Murre, Caroline S., Birshtein, Barbara K., Schork, Nicholas J., Schlissel, Mark S., Riblet, Roy, Murre, Cornelis, Feeney, Ann J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111298/
https://ncbi.nlm.nih.gov/pubmed/21606361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019391108
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