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Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

Toxin–antitoxin (TA) loci are common in archaea and prokaryotes and allow cells to rapidly adapt to changing environmental conditions through release of active regulators of metabolism. Many toxins are endonucleases that target cellular mRNA and tRNAs, while the antitoxins tightly wrap around the to...

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Autori principali: Dienemann, Christian, Bøggild, Andreas, Winther, Kristoffer S., Gerdes, Kenn, Brodersen, Ditlev E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384007/
https://ncbi.nlm.nih.gov/pubmed/22037005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.024
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