Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors

PURPOSE: To identify sources of exposure variability for the tumor growth inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) using a population pharmacokinetic analysis. METHODS: A total 67 solid tumor patients at 2 centers were given 1 h infusions of 17-DMAG either as a single...

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Bibliographic Details
Main Authors: Aregbe, Abdulateef O., Sherer, Eric A., Egorin, Merrill J., Scher, Howard I., Solit, David B., Ramanathan, Ramesh K., Ramalingam, Suresh, Belani, Chandra P., Ivy, Percy S., Bies, Robert R.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2012
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383947/
https://ncbi.nlm.nih.gov/pubmed/22450873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1859-1
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