Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

Dissecting the role of insulin in the complex regulation of triglyceride metabolism is necessary for understanding dyslipidemia and steatosis. Liver Insulin Receptor Knockout (LIRKO) mice show that in the physiological context of feeding, hepatic insulin signaling is not required for the induction o...

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Hlavní autoři: Haas, Joel T., Miao, Ji, Chanda, Dipanjan, Wang, Yanning, Zhao, Enpeng, Haas, Mary E., Hirschey, Matthew, Vaitheesvaran, B., Farese, Robert V., Kurland, Irwin J., Graham, Mark, Crooke, Rosanne, Foufelle, Fabienne, Biddinger, Sudha B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383842/
https://ncbi.nlm.nih.gov/pubmed/22682225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.05.002
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