2-Aminopurine Inhibits Lipid Accumulation Induced by Apolipoprotein E-Deficient Lipoprotein in Macrophages: Potential Role of Eukaryotic Initiation Factor-2α Phosphorylation in Foam Cell Formation

We previously reported that apolipoprotein (Apo) E-deficient, ApoB48-containing (E(−)/B48) lipoproteins inhibited expression of lysosomal hydrolase and transformed mouse peritoneal macrophages (MPMs) into foam cells. The present study examined the effect of 2-aminopurine (2-AP), an inhibitor of euka...

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Bibliographische Detailangaben
Hauptverfasser: Wu, DongFang, Yang, Hong, Zhao, YanFeng, Sharan, Chakradhari, Goodwin, J. Shawn, Zhou, Lichun, Guo, Yang, Guo, ZhongMao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383833/
https://ncbi.nlm.nih.gov/pubmed/18463320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.134833
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