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Biologic impact of proteasome inhibition in MM cells - from the aspects of preclinical studies
The ubiquitin-proteasome pathway (UPP) is a major protein degradation system that maintains homeostasis of intracellular proteins, involved in DNA repair, cell cycle regulation, cell proliferation, and drug resistance. Since numerous proteins are processed by proteasomes, their inhibition triggers d...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383768/ https://ncbi.nlm.nih.gov/pubmed/22726545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminhematol.2012.04.006 |
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