Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6

Obesity and type 2 diabetes are associated with chronically elevated systemic levels of IL-6, a pro-inflammatory cytokine with a role in skeletal muscle metabolism that signals through the IL-6 receptor (IL-6Rα). We hypothesized that skeletal muscle in obesity-associated type 2 diabetes develops a r...

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Bibliographic Details
Main Authors: Scheele, Camilla, Nielsen, Søren, Kelly, Meghan, Broholm, Christa, Nielsen, Anders Rinnov, Taudorf, Sarah, Pedersen, Maria, Fischer, Christian P., Pedersen, Bente Klarlund
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383673/
https://ncbi.nlm.nih.gov/pubmed/22761857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039657
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