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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases
Rho GTPases have been implicated in diverse cellular functions and are potential therapeutic targets. By virtual screening, we have identified a Rho specific inhibitor, Rhosin. Rhosin contains two-aromatic rings tethered by a linker, and it binds to the surface area sandwiching Trp58 of RhoA with a...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383629/ https://ncbi.nlm.nih.gov/pubmed/22726684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.009 |
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