Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

Rho GTPases have been implicated in diverse cellular functions and are potential therapeutic targets. By virtual screening, we have identified a Rho specific inhibitor, Rhosin. Rhosin contains two-aromatic rings tethered by a linker, and it binds to the surface area sandwiching Trp58 of RhoA with a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Shang, Xun, Marchioni, Fillipo, Sipes, Nisha, Evelyn, Chris R., Jerabek-Willemsen, Moran, Duhr, Stefan, Seibel, William, Wortman, Matthew, Zheng, Yi
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383629/
https://ncbi.nlm.nih.gov/pubmed/22726684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.009
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki