Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis

Cytokine-induced beta-cell apoptosis is important to the etiology of type-1 diabetes. Although previous reports have shown that general inhibitors of histone deacetylase (HDAC) activity, such as suberoylanilide hydroxamic acid and trichostatin A, can partially prevent beta-cell death, they do not fu...

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Bibliographic Details
Main Authors: Chou, Danny Hung-Chieh, Holson, Edward B., Wagner, Florence F., Tang, Alicia J., Maglathlin, Rebecca L., Lewis, Timothy A., Schreiber, Stuart L., Wagner, Bridget K.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383610/
https://ncbi.nlm.nih.gov/pubmed/22726680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.010
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