Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis

Fidgetin is a member of the AAA protein superfamily with important roles in mammalian development. Here we show that human Fidgetin is a potent microtubule severing and depolymerizing the enzyme used to regulate mitotic spindle architecture, dynamics and anaphase A. In vitro, recombinant human Fidge...

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Autori principali: Mukherjee, Suranjana, Valencia, J. Daniel Diaz, Stewman, Shannon, Metz, Jeremy, Monnier, Sylvain, Rath, Uttama, Asenjo, Ana B., Charafeddine, Rabab A., Sosa, Hernando J., Ross, Jennifer L., Ma, Ao, Sharp, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383595/
https://ncbi.nlm.nih.gov/pubmed/22672901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20849
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