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NuMA recruits dynein activity to microtubule minus-ends at mitosis

To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into poles. How dynein becomes enriched at minus-e...

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Bibliographic Details
Published in:eLife
Main Authors: Hueschen, Christina L, Kenny, Samuel J, Xu, Ke, Dumont, Sophie
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706958/
https://ncbi.nlm.nih.gov/pubmed/29185983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29328
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