Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. Thus, autophagy and senescence may be part of the same physiological process, known as the autoph...

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Detalhes bibliográficos
Main Authors: Capparelli, Claudia, Guido, Carmela, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Balliet, Renee, Pestell, Timothy G., Goldberg, Allison F., Pestell, Richard G., Howell, Anthony, Sneddon, Sharon, Birbe, Ruth, Tsirigos, Aristotelis, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383590/
https://ncbi.nlm.nih.gov/pubmed/22684298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20718
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