Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. Thus, autophagy and senescence may be part of the same physiological process, known as the autoph...

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Main Authors: Capparelli, Claudia, Guido, Carmela, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Balliet, Renee, Pestell, Timothy G., Goldberg, Allison F., Pestell, Richard G., Howell, Anthony, Sneddon, Sharon, Birbe, Ruth, Tsirigos, Aristotelis, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383590/
https://ncbi.nlm.nih.gov/pubmed/22684298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20718
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