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Do human transposable element small RNAs serve primarily as genome defenders or genome regulators?

It is currently thought that small RNA (sRNA) based repression mechanisms are primarily employed to mitigate the mutagenic threat posed by the activity of transposable elements (TEs). This can be achieved by the sRNA guided processing of TE transcripts via Dicer-dependent (e.g., siRNA) or Dicer-inde...

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Autores principales: Lee, Kevin J., Conley, Andrew B., Lunyak, Victoria V., Jordan, I. King
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383446/
https://ncbi.nlm.nih.gov/pubmed/22754749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mge.19031
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