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Revisiting the Isobole and Related Quantitative Methods for Assessing Drug Synergism
The isobole is well established and commonly used in the quantitative study of agonist drug combinations. This article reviews the isobole, its derivation from the concept of dose equivalence, and its usefulness in providing the predicted effect of an agonist drug combination, a topic not discussed...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383036/ https://ncbi.nlm.nih.gov/pubmed/22511201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.193474 |
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