The α2 helix in the DNA Ligase IV BRCT-1 domain is required for targeted degradation of Ligase IV during adenovirus infection

In adenovirus E4 mutant infections, viral DNAs form concatemers through a process that requires host Non-homologous End Joining (NHEJ) proteins including DNA Ligase IV (LigIV). Adenovirus proteins E4 34k and E1b 55k form the substrate-selection component of an E3 ubiquitin ligase and prevent concate...

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Autores principales: Gilson, Timra, Greer, Amy E., Vindigni, Alessandro, Ketner, Gary, Hanakahi, Leslyn A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382995/
https://ncbi.nlm.nih.gov/pubmed/22534089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.006
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