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The α2 helix in the DNA Ligase IV BRCT-1 domain is required for targeted degradation of Ligase IV during adenovirus infection
In adenovirus E4 mutant infections, viral DNAs form concatemers through a process that requires host Non-homologous End Joining (NHEJ) proteins including DNA Ligase IV (LigIV). Adenovirus proteins E4 34k and E1b 55k form the substrate-selection component of an E3 ubiquitin ligase and prevent concate...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382995/ https://ncbi.nlm.nih.gov/pubmed/22534089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.006 |
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