Zebrafish screen identifies novel compound with selective toxicity against leukemia

To detect targeted antileukemia agents we have designed a novel, high-content in vivo screen using genetically engineered, T-cell reporting zebrafish. We exploited the developmental similarities between normal and malignant T lymphoblasts to screen a small molecule library for activity against immat...

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Autors principals: Ridges, Suzanne, Heaton, Will L., Joshi, Deepa, Choi, Henry, Eiring, Anna, Batchelor, Lance, Choudhry, Priya, Manos, Elizabeth J., Sofla, Hossein, Sanati, Ali, Welborn, Seth, Agarwal, Archana, Spangrude, Gerald J., Miles, Rodney R., Cox, James E., Frazer, J. Kimble, Deininger, Michael, Balan, Kaveri, Sigman, Matthew, Müschen, Markus, Perova, Tatiana, Johnson, Radia, Montpellier, Bertrand, Guidos, Cynthia J., Jones, David A., Trede, Nikolaus S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382926/
https://ncbi.nlm.nih.gov/pubmed/22490804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398818
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