Zebrafish screen identifies novel compound with selective toxicity against leukemia

To detect targeted antileukemia agents we have designed a novel, high-content in vivo screen using genetically engineered, T-cell reporting zebrafish. We exploited the developmental similarities between normal and malignant T lymphoblasts to screen a small molecule library for activity against immat...

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Detalhes bibliográficos
Main Authors: Ridges, Suzanne, Heaton, Will L., Joshi, Deepa, Choi, Henry, Eiring, Anna, Batchelor, Lance, Choudhry, Priya, Manos, Elizabeth J., Sofla, Hossein, Sanati, Ali, Welborn, Seth, Agarwal, Archana, Spangrude, Gerald J., Miles, Rodney R., Cox, James E., Frazer, J. Kimble, Deininger, Michael, Balan, Kaveri, Sigman, Matthew, Müschen, Markus, Perova, Tatiana, Johnson, Radia, Montpellier, Bertrand, Guidos, Cynthia J., Jones, David A., Trede, Nikolaus S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382926/
https://ncbi.nlm.nih.gov/pubmed/22490804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398818
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