Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo

The relatively low frequencies of tumor Ag-specific T-cells in PBMC and metastases from cancer patients have long precluded the analysis of their direct ex vivo cytolytic capacity. Using a new composite technique that works well with low cell numbers, we aimed at determining the functional competenc...

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Main Authors: Mahnke, Yolanda D., Devevre, Estelle, Baumgaertner, Petra, Matter, Maurice, Rufer, Nathalie, Romero, Pedro, Speiser, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382891/
https://ncbi.nlm.nih.gov/pubmed/22754765
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