Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo

Murine IgG3 anti-GD2 antibody m3F8 has shown anti-neuroblastoma activity in Phase I/II studies, where antibody-dependent cell-mediated cytotoxicity (ADCC) played a key role. Humanization of m3F8 should circumvent human anti-mouse antibody (HAMA) response and enhance its ADCC properties to reduce dos...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Cheung, Nai-Kong V., Guo, Hongfen, Hu, Jian, Tassev, Dimiter V., Cheung, Irene Y.
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2012
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382886/
https://ncbi.nlm.nih.gov/pubmed/22754766
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍