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Antitumor efficacy of anti-GD2 IgG1 is enhanced by Fc glyco-engineering
The affinity of therapeutic antibodies for Fcγ-receptors (FcγRs) strongly influences their antitumor potency. To generate antibodies with optimal binding and immunologic efficacy, we compared the affinities of different versions of an IgG1 Fc region that had an altered peptide backbone, altered glyc...
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| Veröffentlicht in: | Cancer Immunol Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4948116/ https://ncbi.nlm.nih.gov/pubmed/27197064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0221 |
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