Breaking the tolerance for tumor: Targeting negative regulators of TLR signaling

Tumors arise and progress in immunocompetent hosts presumably by activating tolerance mechanisms critical for normal homeostasis. Host immune cells can mount anti-tumor responses by activation of Toll-like receptors (TLRs). However, emerging data suggests that molecules that negatively regulate TLRs...

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Bibliographic Details
Main Authors: Standiford, Theodore J., Keshamouni, Venkateshwar G.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382869/
https://ncbi.nlm.nih.gov/pubmed/22737610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.18434
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