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Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for imped...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382849/ https://ncbi.nlm.nih.gov/pubmed/22737630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.19123 |
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