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Activation of antigen-exposed iMC-DCs at the “right place” and “right time” promotes potent anti-tumor immunity
To better control the “licensing” of pro-Th1 dendritic cells (DCs), Spencer and colleagues have developed a synthetic ligand-inducible chimeric receptor, iMyD88/CD40 (iMC), incorporating synergistic Toll-like receptor (TLR) and costimulatory signaling elements, permitting DC regulation in vivo withi...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382847/ https://ncbi.nlm.nih.gov/pubmed/22737615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.18482 |
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