Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis. The mechanism of inhibition involves th...

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Detalhes bibliográficos
Main Authors: Qu, LiKe, Huang, Shirley, Baltzis, Dionissios, Rivas-Estilla, Ana-Maria, Pluquet, Olivier, Hatzoglou, Maria, Koumenis, Costas, Taya, Yoichi, Yoshimura, Akihiko, Koromilas, Antonis E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338280/
https://ncbi.nlm.nih.gov/pubmed/14744935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1165804
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