Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis. The mechanism of inhibition involves th...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Qu, LiKe, Huang, Shirley, Baltzis, Dionissios, Rivas-Estilla, Ana-Maria, Pluquet, Olivier, Hatzoglou, Maria, Koumenis, Costas, Taya, Yoichi, Yoshimura, Akihiko, Koromilas, Antonis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC338280/
https://ncbi.nlm.nih.gov/pubmed/14744935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1165804
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky