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Fighting cancer by disrupting C-terminal methylation of signaling proteins

Protein methylation at the C-terminus of mammalian isoprenylated proteins has been implicated in membrane attachment, protein-protein interactions, and protein stability. A new paper describes surprising results: in the absence of methylation some target proteins have increased stability, whereas ot...

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Detalhes bibliográficos
Main Authors: Clarke, Steven, Tamanoi, Fuyuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338270/
https://ncbi.nlm.nih.gov/pubmed/14966560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421059
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