β-Catenin Loss in Hepatocytes Promotes Hepatocellular Cancer after Diethylnitrosamine and Phenobarbital Administration to Mice

Hepatocellular Carcinoma (HCC) is the fifth most common cancer worldwide. β-Catenin, the central orchestrator of the canonical Wnt pathway and a known oncogene is paramount in HCC pathogenesis. Administration of phenobarbital (PB) containing water (0.05% w/v) as tumor promoter following initial inje...

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Autors principals: Awuah, Prince Kwaku, Rhieu, Byung Han, Singh, Sucha, Misse, Amalea, Monga, Satdarshan P. S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382575/
https://ncbi.nlm.nih.gov/pubmed/22761897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039771
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