Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis

Use of long-term constitutive expression of VEGF for therapeutic angiogenesis may be limited by the growth of abnormal blood vessels and hemangiomas. We investigated the relationship between VEGF dosage and the morphology and function of newly formed blood vessels by implanting retrovirally transduc...

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Bibliografiske detaljer
Main Authors: Ozawa, Clare R., Banfi, Andrea, Glazer, Nicole L., Thurston, Gavin, Springer, Matthew L., Kraft, Peggy E., McDonald, Donald M., Blau, Helen M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC338257/
https://ncbi.nlm.nih.gov/pubmed/14966561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418420
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