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Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches
Cyclin-dependent kinase 1 (Cdk1) kinase dephosphorylation and activation by Cdc25 phosphatase are essential for mitotic entry. Activated Cdk1 phosphorylates Cdc25 and other substrates, further activating Cdc25 to form a positive feedback loop that drives the abrupt G2/mitosis switch. Conversely, mit...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382524/ https://ncbi.nlm.nih.gov/pubmed/22665807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201366109 |
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